By W. N. Aldridge (eds.)
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Additional info for A Symposium on Mechanisms of Toxicity
When later on, the cottonwool was again removed the rate of fall resumed its previous steepness as the tail-response was still on. (A few days after the meeting the results of the experiment with the tail-less rats were known. It appeared that following a suitable dose of soman eight normal rats produced an average hypothermia of 5·53° ± O·l8°C whereas the eight rats which had their tails amputated 5 days previously showed a hypothermia of 4·01° ± O·l4°C. The time of minimum temperature was exactly equal in both groups.
11, treatment of X with calf intestine alkaline phosphatase led to equimolar formation of methionine sulphoximine and inorganic phosphate. These experiments therefore show that inhibition of glutamine synthetase by methionine sulphoximine involves binding of methionine sulphoximine to the enzyme in the form of a phosphoryl derivative; an equimolar amount of ADP is also bound. The evidence suggests that methionine sulphoximine phosphate is not bound covalently for it is readily released by treatment of the inhibited enzyme with perchloric acid or by brief heating at 100°C.
Influence of intraventricular soman on the set point for heat release (SPHR). Three different rats (weight approx. tg soman respectively each in a volume of 25 ~-tl. E. Meeter 36 cold-exposure (1 h at 20°C below room temperature) before and after administration of soman. During the first cold-exposure the rats underwent a fall in body temperature of 0·45°C. All had pilo-erection at the first measurement in the cold, and somewhat later all animals except one started to shiver. Following the development of soman-hypothermia the coldexposure was repeated with the result that the body temperature fell4·8°C.